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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. s1, 1999, pp. 135-137
Bioline Code: oc99145
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. s1, 1999, pp. 135-137

 en Features of Host Cell Invasion by Different Infective Forms of Trypanosoma cruzi
Renato A Mortara; Daniela O Procópio; Helena C Barros; Newton V Verbisck; Walter K Andreoli; Ricardo BS Silva & Solange da Silva


Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system. We have been interested in several aspects of in vitro interactions of different infective forms of the parasite with cultured mammalian cells. We have observed that not only the classically infective trypomastigotes but also amastigotes, originated from the extracellular differentiation of trypomastigotes, can infect cultured cells. Interestingly, the process of invasion of different parasite infective forms is remarkably distinct and also highly dependent on the host cell type.

Trypanosoma cruzi - cell invasion - amastigote - trypomastigote

© Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz
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