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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. s1, 1999, pp. 149-152
Bioline Code: oc99148
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. s1, 1999, pp. 149-152

 en Trypanosoma cruzi-cardiomyocytes: New Contributions Regarding a Better Understanding of this Interaction
Maria de Nazareth Leal de Meirelles; Mirian Claudia S Pereira; Robert H Singer; Maria de Nazaré C Soeiro; Luciana R Garzoni; Dayse T Silva; Helene S Barbosa; Tania C Araujo-Jorge; Masako O Masuda; Marcia AM Capella; Anibal Gil Lopes & Alane B Vermelho

Abstract

The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of the parasite. One of the most striking events
in the parasite-heart muscle cells interaction is the disruption of the actin cytoskeleton. We have investigated the regulation of the actin mRNA during the cytopathology induced in myocardial cells by
the parasite. T. cruzi invasion increases calcium resting levels in cardiomyocytes. We have previously shown that Ca2+ ATPase of the sarcoplasmic reticulum (SERCA) is involved in the invasion of T. cruzi in cardiomyocytes. Treating the cells with thapsigargin, a drug that binds to all SERCA ATPases and causes depletion of intracellular calcium stores, we found a 75% inhibition in the T. cruzi-cardiomyocytes invasion.

Keywords
Trypanosoma cruzi - cardiomyocytes - calcium - SERCA ATPases - mannose receptor - mRNA regulation

 
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