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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. s1, 1999, pp. 257-262
Bioline Code: oc99174
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. s1, 1999, pp. 257-262

 en Immunopathology of Cardiomyopathy in the Experimental Chagas Disease
Milena BP Soares & Ricardo Ribeirodos Santos

Abstract

The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T.cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation.

Keywords
cardiomyopathy - immunopathology - Chagas disease - Trypanosoma cruzi

 
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