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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. s1, 1999, pp. 263-267
Bioline Code: oc99175
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. s1, 1999, pp. 263-267

 en Human Chronic Chagasic Cardiopathy: Participation of Parasite Antigens, Subsets of Lymphocytes, Cytokines and Microvascular Abnormalities
Maria de Lourdes Higuchi

Abstract

This article tries to demonstrate by new pathological findings (with the use of immunohistochemical technique and confocal laser microscopy) that chronic chagasic cardiomyopathy is a result of multiple factors involving myocarditis, immunodepression, severe fibrosis and microvessels dilatation and
that all of these alterations are probably directly related with the presence of Trypanosoma cruzi parasites in the host associated with inadequate immunological response of the host.

Keywords
Chagas disease - myocarditis - Trypanosoma cruzi - immunodepression

 
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