Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 94, No. 6, 1999, pp. 791-794
Bioline Code: oc99231
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 6, 1999, pp. 791-794
© Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz
Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis|
Araujo, Catarina A.C.; Alegrio, Leila V.; Gomes, Denise C.F.; Lima, Marco Edilson F.; Gomes-Cardoso, Leonardo & Leon, Leonor L.
In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from
curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L. amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C. sclerophyllum.
Leishmania amazonensis - Centrolobium sclerophyllum - diarylheptanoids
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