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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 94, No. 6, 1999, pp. 791-794
Bioline Code: oc99231
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 94, No. 6, 1999, pp. 791-794

 en Studies on the Effectiveness of Diarylheptanoids Derivatives against Leishmania amazonensis
Araujo, Catarina A.C.; Alegrio, Leila V.; Gomes, Denise C.F.; Lima, Marco Edilson F.; Gomes-Cardoso, Leonardo & Leon, Leonor L.

Abstract

In a previous work we demonstrated that diarylheptanoids extracted from Centrolobium sclerophyllum are very active against Leishmania amazonensis promastigotes. In order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of L. amazonensis. Furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-O-methylcentrolobine, the most active diarylheptanoid derived from C. sclerophyllum.

Keywords
Leishmania amazonensis - Centrolobium sclerophyllum - diarylheptanoids

 
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