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Indian Journal of Occupational and Environmental Medicine
Medknow Publications
ISSN: 0973-2284
EISSN: 1998-3670
Vol. 10, No. 1, 2006, pp. 24-27
Bioline Code: oe06005
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Occupational and Environmental Medicine, Vol. 10, No. 1, 2006, pp. 24-27

 en Altered pituitary hormone secretion in male rats exposed to bisphenol A
Gharravi AM, Ghorbani R, Khazaei M, Motabbad PourA, Al Agha M, Ghasemi J, Sayadi P

Abstract

Bisphenol A (BPA) is a xenobiotic estrogenic compound. This compound has been suspected to have estrogenic effects on reproductive system of males and females. In this present study we investigated possible low-dose effects of BPA on Luteinizing Hormone in rats. Male Wistar rats (12-13 weeks old) were administrated a daily intra peritoneal 10 μg/kgbw/day, 50 μg/kgbw/day, 100 μg/kgbw/day dose of BPA for 6, 6, and 12 days, and one day after last injection, serum level of Luteinizing Hormone was examined by ELISA method. All data were expressed as means ± SE. Two-way ANOVA was performed. Analysis of data showed that in all dose groups, plasma level of Luteinizing Hormone significantly decreased compared to control group. The present study showed that BPA at low doses affects Luteinizing Hormone, one of main hormones in spermatogenesis in the adult Wistar rats, and subsequently alters the steroidgenesis in testicular Leydig cells.

Keywords
Bisphenol A, luteinizing hormone, spermatogenesis

 
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