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Indian Journal of Occupational and Environmental Medicine
Medknow Publications
ISSN: 0973-2284 EISSN: 0973-2284
Vol. 12, No. 3, 2008, pp. 107-111
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Bioline Code: oe08029
Full paper language: English
Document type: Review Article
Document available free of charge
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Indian Journal of Occupational and Environmental Medicine, Vol. 12, No. 3, 2008, pp. 107-111
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Neopterin: Biomarker of Cell-mediated Immunity and Potent Usage as Biomarker in Silicosis and Other Occupational Diseases
Pingle, Shubhangi K.; Tumane, Rajani G. & Jawade, Aruna A.
Abstract
Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with γ-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.
Keywords
Biomarker, cell-mediated immunity, γ-interferon, neopterin, silicosis, tryptophan degradation
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© Copyright 2008 Indian Journal of Occupational and Environmental Medicine. Alternative site location: http://www.ijoem.com
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