search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Indian Journal of Occupational and Environmental Medicine
Medknow Publications
ISSN: 0973-2284
EISSN: 1998-3670
Vol. 14, No. 2, 2010, pp. 31-38
Bioline Code: oe10011
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Occupational and Environmental Medicine, Vol. 14, No. 2, 2010, pp. 31-38

 en An overview of caspase: Apoptotic protein for silicosis
Tumane, Rajani G.; Pingle, Shubhangi K.; Jawade, Aruna A. & Nath, Nirmalendu N.

Abstract

Silicosis is a chronic lung disease characterized by granulomatous and fibrotic lesions, which occurs due to accumulation of respirable silica mineral particles. Apoptosis is an important phenomenon of cell death in silicosis. The relationship between silica dust and its exposure is well established. But, the complex chain of cellular responses, which leads to caspase activation in silicosis, has not been fully discovered. Caspase activation plays a central role in the execution of apoptosis. Silica-induced apoptosis of the alveolar macrophages could potentially favor a proinflammatory state, occurring in the lungs of silicotic patients, resulting in the activation of caspase prior to induction of the intrinsic and extrinsic apoptosis pathways. Recent studies indicated that apoptosis may involve in pulmonary disorders. This review summarizes the current knowledge about the underling mechanism of biochemical pathways in caspase activation that have been ignored so far in silicosis. In addition, caspase could be a key apoptotic protein that can be used as an effective biomarker for the study of occupational diseases. It may provide an important link in understanding the molecular mechanisms of silica-induced lung pathogenesis.

Keywords
Apoptosis, caspase, DNA adduction, Fas/FasL, occupational diseases and silicosis

 
© Copyright 2010 Indian Journal of Occupational and Environmental Medicine.
Alternative site location: http://www.ijoem.com

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2020, Site last up-dated on 07-Jul-2020.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil