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Brazilian Journal of Oral Sciences
Piracicaba Dental School - UNICAMP
EISSN: 1677-3225
Vol. 7, No. 24, 2008, pp. 1470-1475
Bioline Code: os08001
Full paper language: English
Document type: Research Article
Document available free of charge

Brazilian Journal of Oral Sciences, Vol. 7, No. 24, 2008, pp. 1470-1475

 en Drugs and nonsyndromic orofacial cleft: an update
Palmieri, Annalisa; Avantaggiato, Anna; Arlotti, Giorgio Brunelli Marzia; Scapoli, Luca; Martinelli, Marcella; Pezzetti, Furio & Carinci, Francesco


Nonsyndromic orofacial cleft (OFC) derives from an embryopathy with failure of the nasal processes and/or fusion of the palatal shelves. This severe birth defect is one of the most common malformations among live births. Human cleft is composed of two separate entities: cleft of the lip with or without palate (CL±P) and cleft palate only (CPO). Both have a genetic origin, whereas environmental factors contribute to these congenital malformations. In this review we analyze the role of drugs related to the onset of cleft. The data were obtained from (i) epidemiologic studies (ii) animal models and (iii) human genetic investigations. These studies have demonstrated a relation between certain drugs (steroids and anticonvulsants) taken during pregnancy and a higher risk of generating offspring with OFC whereas no clear relation has been demonstrated between aspirin and OFC.

Cleft; Steroid, Anticonvulsivant; Cortisone; Phenytoin

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