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Brazilian Journal of Oral Sciences
Piracicaba Dental School - UNICAMP
EISSN: 1677-3225
Vol. 7, No. 24, 2008, pp. 1520-1526
Bioline Code: os08010
Full paper language: English
Document type: Research Article
Document available free of charge

Brazilian Journal of Oral Sciences, Vol. 7, No. 24, 2008, pp. 1520-1526

 en Cytotoxicity of intraoral orthodontic elastics
Santos, Rogério Lacerda Dos; Pithon, Matheus Melo; de Oliveira, Márlio Vinícius de; Mendes, Gabriella da Silva; Romanos, Maria Teresa Villela & Ruellas, Antônio Carlos de Oliveira


Aim: The present study compared in vitro four types of latex intraoral elastics (5/16 = 7.9 mm, mean load) regarding their possible cytotoxic effects.
Material and Methods: The sample was allocated to four groups of 24 elastics: Group A (American Orthodontics), Group M (Morelli), Group T (TP Orthodontics), and Group U (Uniden). Cytotoxicity assays were performed using cell culture medium containing epithelioid-type cells (Hep-2 line) derived from human laryngeal carcinoma. Two methods for evaluating the cytotoxicity, the agar overlay test and "dye-uptake" test, were employed at two different moments (0 and 24 h). Data were compared by analysis of variance (ANOVA) and Tukey's test (p<0.05).
Results: The results showed statistically significant difference (p<0.05) between Groups T and M, T and U, A and M, and A and U, for dye-uptake test at 0 and 24 h. No cell lysis was found in Groups T and A for the agar overlay test, whereas 80% cell lysis was found in Groups M and U after 24 h according to the Stanford's response index (RI).
Conclusion: Both TP Orthodontics and American Orthodontics elastics evoked less cell lysis than Morelli and Uniden elastics.

cytotoxicity; elastics; biocompatibility; orthodontics

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