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Brazilian Journal of Oral Sciences
Piracicaba Dental School - UNICAMP
EISSN: 1677-3225
Vol. 8, No. 4, 2009, pp. 197-200
Bioline Code: os09042
Full paper language: English
Document type: Research Article
Document available free of charge

Brazilian Journal of Oral Sciences, Vol. 8, No. 4, 2009, pp. 197-200

 en DNA damage in viscose factory workers occupationally exposed to carbon di-sulfide using buccal cell comet assay
Manikantan, Pappuswamy; Balachandar, Vellingiri; Sasikala, Keshavarao & Mohanadevi, Subramanium

Abstract

Aim: The most important industrial use of carbon disulfide (CS2 ) has been in the fabrication of regenerated cellulose rayon by the viscose process and cellophane. CS 2 leads to increased frequency of chromosomal aberrations in workers with occupational exposure to CS 2 . Methods: In the present study, the DNA damage was analyzed by using buccal cell comet assay for 30 viscose plant workers who are occupationally exposed to CS 2 and 30 healthy individuals. Both groups were classified as smokers and non-smokers and only the experimental subjects were classified based on the exposure period. The data were analyzed statistically by the Student′s t-test. Results: The results of this study showed increased levels of DNA damage among viscose plant workers. Conclusion: The habit of cigarette smoking among the viscose workers had a synergistic effect on inducing DNA damage.

Keywords
carbon di-sulphide, DNA damage, smoking, buccal cell comet assay

 
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