Serum Lipid and Blood Pressure Levels in Children and Adolescent Aged 3-18 Years with History of Early Onset Myocardial Infarction in Their Parents: A Case Control Study|
Zand, Soliman; Koohestani, Hamid-Reza; Baghcheghi, Naiereh & Rezai, Korosh
Atherosclerosis is a process that begins during childhood, progresses asymptomatically,
and generally shows no clinical manifestations until adulthood. Hyperlipidemia and high blood
pressure have been associated with an increased risk of atherosclerosis and cardiovascular disease.
The purpose of this study was to evaluate the serum lipid and blood pressure levels in children and
adolescents aged 3-18 years with the history of early onset of myocardial infarction in their
parents; and to compare them with the control group.
This is a case-control study in which 209 children and adolescents, aged 3-18 years,
with a family history of early onset myocardial infarction as case group were selected and
compared to 209 individuals of the same age group, without the history of early onset myocardial
infarction as the control group. Their serum lipid and blood pressure levels were measured. Data
was analyzed by SPSS software.
Mean cholesterol, LDL and triglycerides were 171.64, 112.26 and 97.32 mg/dl,
respectively in the case group; 150.04, 104.82 and 181.57 mg/dl in the control group which
showed significant difference. Mean HDL level was 38.86 mg/dl in the case and 39.59 mg/dl in
the control group which had no significant difference. Mean systolic and diastolic blood pressure
were 110/22 and 71/84 mmHg in the case and 99/13 and 60/31 mmHg in the control group that
shows significant difference.
Serum lipid and blood pressure levels in children and adolescents with a history of
early onset myocardial infarction in their parents are higher in the control group, therefore, these
children are at high risk for coronary artery disease.
Serum lipid; Blood pressure; Children; Parents; Early onset myocardial infarction