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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 18, No. s1, 2008, pp. 81-87
Bioline Code: pe08076
Full paper language: Farsi
Document type: Review Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 18, No. s1, 2008, pp. 81-87

 en Acute Disseminated Encephalomyelitis
Khosroshahi, Nahid & Sotoudeh, Kambiz

Abstract

Acute disseminated encephalomyelitis (ADEM) is an acute, inflammatory, monophasic, demyelinating and immune-mediated disorder of central nervous system; occurs mostly in children after systemic viral infections or vaccinations. Acute polysymptomatic neurologic signs such as encephalopathy, paralysis of limbs, cranial nerve involvement, ataxia and optic neuritis are common manifestations. Brain magnetic resonance imaging study is essential for diagnosis and enabling prompt diagnosis and treatment. Evidence of multifocal lesions of demyelination in subcortical white matter are seen. They are usually bilateral and asymmetrical. Treatment optins have included steroids, immunoglobulins, and plasmapheresis. ADEM is treatable and prognosis is good.

Keywords
Acute disseminated encephalomyelitis; Children; Demyelination; ADEM

 
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