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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 19, No. 1, 2009, pp. 52-58
Bioline Code: pe09008
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 19, No. 1, 2009, pp. 52-58

 en Acute Inflammatory Demyelinating Polyneuropathy in Children; Clinical and Electrophysiologic Findings
Shamsabadi, Farhad Mahvelati; Karimzadeh, Parvaneh; Tonekaboni, Seyed-Hasan & Ghorobi, Javad

Abstract

Objective: The aim of this study was to evaluate the electrophysiologic findings of Guillain Barre Syndrome (GBS) in children and their relation with clinical progress of the disease.
Methods: Twenty-three children with GBS were evaluated between 2005 and 2007. Electrophysiologic evaluations were performed at admission and one month later.
Findings: Five patients needed respirator, 15 were bedridden, 1 developed recurrence 6 months later, and 2 experienced chronic GBS. The most common findings included: decreased amplitude of muscle action potential (CMAP) (96%), increased distal latency (74%), increased F wave latency (69%), and decreased nerve conduction velocity (NCV) (61%). Sensory nerve conduction (evaluating sural nerve) was normal in 78% of the cases. These measures did not significantly change after 1 month.
Conclusion: Electrodiagnostic evaluations are helpful at the primary stages of GBS for diagnosis. Fibrillation potentials and positive sharp waves showing denervation and axonal injury are presentative of longer duration of the disease and a worse prognosis.

Keywords
Guillain Barre Syndrome, Electrophysiologic evaluations, Acute flaccid paralysis, Acute inflammatory demyelinating polyneuropathy

 
© © 2009 by Center of Excellence for Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences,All rights reserved.
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