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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 19, No. 2, 2009, pp. 130-134
Bioline Code: pe09020
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 19, No. 2, 2009, pp. 130-134

 en Serum Copper Concentration in Newborns with Neural Tube Defects in Northern Iran; A Case Control Study
Golalipour, Mohammad-Jafar; Mansourian, Azad-Reza & Keshtkar, Abbas-Ali


Objective: This study was conducted to determine the eventual association between copper deficiency in newborns with neural tube defects (NTD) in Northern Iran. A high prevalence of neural tube defects has been reported from this region.
Methods: This hospital based case control study was carried out on 13 newborns having neural tube defects and 35 healthy controls in Northern Iran during 2005-2006. Serum copper was measured by spectrophotometery.
Findings: Serum copper level in newborns with NTD and healthy normal newborns was 16.5 (±7.2) μmol/l and 16.7 (±6.6) μmol/l, respectively. In case group 38.5% of newborns and in control group 28.6% had copper deficiency. Logistic regression analysis showed no association between the presence of NTD and copper deficiency (OR:1.6, 95% CI=0.3-7.1, P=0.5).
Conclusion: This study showed no association between NTD and copper deficiency in newborns.

Neural tube defects, Spina bifida, Anencephaly, Copper, Newborns

© © 2009 by Center of Excellence for Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences,All rights reserved.
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