Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 19, No. 2, 2009, pp. 130-134
Bioline Code: pe09020
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 19, No. 2, 2009, pp. 130-134
© © 2009 by Center of Excellence for Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences,All rights reserved.
Serum Copper Concentration in Newborns with Neural Tube Defects in Northern Iran; A Case Control Study|
Golalipour, Mohammad-Jafar; Mansourian, Azad-Reza & Keshtkar, Abbas-Ali
This study was conducted to determine the eventual association between copper deficiency in newborns with neural tube defects (NTD) in Northern Iran. A high prevalence of neural tube defects has been reported from this region.
This hospital based case control study was carried out on 13 newborns having neural tube defects and 35 healthy controls in Northern Iran during 2005-2006. Serum copper was measured by spectrophotometery.
Serum copper level in newborns with NTD and healthy normal newborns was 16.5 (±7.2) μmol/l and 16.7 (±6.6) μmol/l, respectively. In case group 38.5% of newborns and in control group 28.6% had copper deficiency. Logistic regression analysis showed no association between the presence of NTD and copper deficiency (OR:1.6, 95% CI=0.3-7.1, P=0.5).
This study showed no association between NTD and copper deficiency in newborns.
Neural tube defects, Spina bifida, Anencephaly, Copper, Newborns
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