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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 19, No. 2, 2009, pp. 193-195
Bioline Code: pe09032
Full paper language: English
Document type: Case Report
Document available free of charge

Iranian Journal of Pediatrics, Vol. 19, No. 2, 2009, pp. 193-195

 en Neonatal Giant Cell Hepatitis in an Infant with Cystic Fibrosis
Fallahi, Gholamhossein; Bazvand, Fatemeh; Eftekhari, Kambiz; Ahmadi, Faezeh; Ahmadi, Maedeh & Rezaei, Nima


Background: Cystic fibrosis is a hereditary disease of mucus and sweat glands characterized by respiratory infections and pancreatic insufficiency.
Case presentation: We describe a girl infant with cholestasis as of the first clinical presentation at the age of 1 month. She developed severe anemia which required transfusion for several times. High level of direct bilirubin, low level of albumin and positive sweat tests were detected in laboratory tests. Histopathology report of liver biopsy indicated giant cell neonatal hepatitis.
Conclusion: Although neonatal hepatitis is common cause of neonatal cholestasis, such condition is quite rare in cystic fibrosis, which easily could be misdiagnosed. Early diagnosis and appropriate treatment could prevent further complications of the disease.

Cystic Fibrosis, Cholestasis, Giant cell hepatitis, Neonatal hepatitis

© © 2009 by Center of Excellence for Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences,All rights reserved.
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