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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 20, No. 1, 2010, pp. 127-130
Bioline Code: pe10019
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 20, No. 1, 2010, pp. 127-130

 en Congenital Diaphragmatic Hernia Following Usage of Lithium Carbonate; Is Lithium a Teratogen?
Hosseini, Seyed-Hamzeh; Mousavi, Seyed-Abdolah & Rashidi, Houman

Abstract

Background: Lithium is used mainly for the treatment of Bipolar Disorder (BD). Case reports and several retrospective studies have demonstrated possible teratogenicity, but the data in different studies is inconclusive. The risk for cardiovascular malformations, particularly Ebstein’s anomaly and other congenital abnormalities have been reported.
Case Presentation: A 25-year-old gravida 1, para 1 woman at 38 weeks of gestation was admitted for an elective caesarean section. She had a history of BP for which she was treated with lithium 600mg q12h in the first trimester of pregnancy. There was no familial history of birth defects, any antenatal infection or exposure to any other medications, alcohol, smoking, or X-rays. A baby boy (3500g) was born. After 2 to 3 hours respiratory distress clinical picture and chest radiograph suggested diagnosis of congenital diaphragmatic hernia. Repair of his diaphragm was preformed and patient discharged after 12 days.
Conclusion: Lithium probably produces a defect in normal development of the diaphragm and may pose specific risk for an anomaly known as congenital diaphragmatic hernia (CDH).

Keywords
Diaphragmatic Hernia; Lithium Carbonate; Pregnancy; Teratogens; Bipolar Disorder

 
© © 2010 by Center of Excellence for Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences,All rights reserved.
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