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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 20, No. 3, 2010, pp. 297-302
Bioline Code: pe10044
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 20, No. 3, 2010, pp. 297-302

 en Zinc and Copper Status in Children with Beta-Thalassemia Major
Mahyar, Abolfazl; Ayazi, Parviz; Pahlevan, Ali-Asghar; Mojabi, Hoshyar; Sehhat, Mohammad-Reza & Javadi, Amir

Abstract

Objective: There are some reports in which a condition of zinc deficiency and its associated outcomes with a change in concentration of serum copper among the thalassemic patients has been highlighted. The aim of this prospective study was to determine the serum zinc and copper levels in children with beta-thalassemia major.
Methods: In this cross sectional study all children under 12 years affected by beta thalassemia major (40 patients) were evaluated for serum zinc and copper levels in Qazvin thalassemia center (Qazvin, Iran) in 2007. Serum measurements for zinc and copper were performed by atomic absorption spectrophotometer.
Findings: The mean concentrations of serum zinc and copper levels were 67.35±20.38 and 152.42±24.17 μg/dl respectively. Twenty-six (65%) of thalassemic patients had zinc concentration under 70 μg/dl (hypozincemia). None of the thalassemic children had copper deficiency. No significant correlation between serum zinc level with age, weight, height, body mass index, duration of blood transfusion, desferrioxamine dose and ferritin level was observed in thalassemic patients (P=0.3).
Conclusion: This study revealed that hypozincemia is common in thalassemic patients, but in contrast, there is no copper deficiency. Further evaluation in this regard is recommended.

Keywords
Beta-thalassemia; Zinc; Copper; Children

 
© Copyright 2010 Iran Journal of Pediatrics.
Alternative site location: http://diglib.tums.ac.ir/pub/

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