Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 21, No. 3, 2011, pp. 301-306
Bioline Code: pe11051
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 21, No. 3, 2011, pp. 301-306
© Copyright 2011 Iran Journal of Pediatrics.
Association of Serum Soluble Triggering Receptor Expressed on Myeloid Cells Levels in Malignant Febrile Neutropenic Patients with Bacteremia and Fungemia|
Arzanian, Mohammad-Taghi; Soltani, Abolfazl; Attaran, Davood; Fahimzad, Alireza; Shiva, Farideh; Shamshiri, Ahmad-Reza & Karimi, Abdollah
Objective: Infections are the major cause of morbidity and mortality in febrile neutropenic patients
with malignancy. Rapid diagnostic tests are needed for prompt diagnosis and early treatment
which is crucial for optimal management. We assessed the utility of soluble triggering receptor
expressed on myeloid cells (sTREM-1) in the diagnosis of bacteremia and fungemia in febrile
Methods: Sixty-five febrile neutropenic children with malignancy hospitalized in Mofid Children's
Hospital during a period of one year from January 2007 were recruited for this cross sectional
study (mean age 66.2± 37 months; 35 females and 30 males). Thirty patients (46.2%) had acute
lymphoblastic leukemia, 2 (3.1%) acute myeloid leukemia, one (1.5%) lymphoma and 32 (49.2%)
were under treatment for solid tumors. Simultaneous blood samples were collected for
measurement of serum sTREM-1 levels and for blood cultures which were grown in BACTEC
media. Gold standard for the presence of infection was a positive BACTEC culture as a more
sensitive method compared to current blood culture techniques.
Findings: Blood cultures with BACTEC system were positive in 13(20%) patients (12 bacterial and
one fungal culture). The mean serum sTREM-1 level in BACTEC positive patients was 948.2±592.9
pg/ml but in BACTEC negative cases it was 76.3±118.8 pg/ml (P<0.001). The optimal cut-off point
of sTREM-1 for detecting patients with positive result of BACTEC was 525 pg/ml with sensitivity
and specificity of 84.6% and 100%, respectively.
Conclusion: Our study revealed a significant association between serum sTREM-1 level and
bacteremia and fungemia in febrile neutropenic patients suffering malignancy with acceptable
sensitivity and specificity.
Neutropenia; Fever; sTREM-1; BACTEC; Malignancy
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