Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 21, No. 3, 2011, pp. 357-361
Bioline Code: pe11059
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 21, No. 3, 2011, pp. 357-361
© Copyright 2011 Iran Journal of Pediatrics.
The Role of Electron Microscopy for the Diagnosis of Childhood Glomerular Diseases|
Jahanzad, Isa; Mehrazma, Mitra & Makhmalbaf, Ahmad Ostadali
Objective: Optimum diagnosis of glomerulopathies requires light microscopy,
immunofluorescence and electron microcopy. In fact electron microscopy has a confirmatory role
in glomerular diseases. It provides more information for patient management and can rule out
other diseases. The goal of the present study is analysis the necessity of electron microscopy for
the diagnosis of childhood glomerulopathies.
Methods: 134 cases of renal biopsy with some clinical data retrospectively were reviewed. The
contribution of electron microscopy to the final diagnosis was graded as necessary - diagnosis
could not be reached without it, supportive - it increased the level of confidence in the final
diagnosis and noncontributory - the diagnosis don't need electron microscopy for confirmation.
Findings: The contribution of electron microscopy to the final diagnosis was necessary in 51 cases
(38%), supportive in 40 cases (≈30%) and noncontributory in 43 cases (32%).
Conclusion: In conclusion the results showed in about 68% of childhood glomerulopathies the
ultrastructural study was necessary or supportive, so electron microscopy still remains an
important tool in diagnosis of childhood glomerulopathies.
Electron Microscopy; Children; Glomerular Disease; Renal Biopsy
Alternative site location: http://diglib.tums.ac.ir/pub/