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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 21, No. 3, 2011, pp. 362-366
Bioline Code: pe11060
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 21, No. 3, 2011, pp. 362-366

 en Hirschsprung's Disease: a Clinical and Pathologic Study in Iranian Constipated Children
Monajemzadeh, Maryam; Kalantari, Mehdi; Yaghmai, Bahareh; Shekarchi, Roya; Mahjoub, Fatemeh & Mehdizadeh, Mehrzad


Objective: Hirschsprung's disease (HD) is a complex disorder resulting from absence of ganglion cells in the bowel wall leading to functional obstruction and bowel dilatation proximal to the affected segment. The aim of our study was to evaluate rectal biopsies from constipated children in different age groups to see in which age it is more likely to encounter HD to avoid unnecessary rectal biopsy.
Methods: Records of all children with chronic constipation undergoing a rectal biopsy to exclude HD were obtained from the files of Children's Medical Center in Tehran, Iran. A detailed retrospective demographic review, including age of beginning of signs and symptoms was made of all cases.
Findings: Totally, 172 biopsies were taken from 168 children in a five year period, of which 127 cases (75%) had HD. The mean age of constipated patients at biopsy was 39 months and the mean age of patients with proven HD was 18 months. Males were affected more than females. Congenital anomalies associated with HD were found in 9.6%. In 85 (91%) cases constipation had begun in neonatal period.
Conclusion: Our data supports previous studies that if constipation begins after the neonatal period, the child is unlikely to have HD. In neonates delay in meconium passage is the most important clinical sign of HD.

Hirschsprung's Disease; Functional Gastrointestinal Disorders; Constipation; Biopsy; Intestinal Obstruction

© Copyright 2011 Iran Journal of Pediatrics.
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