|
Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 21, No. 3, 2011, pp. 362-366
|
Bioline Code: pe11060
Full paper language: English
Document type: Research Article
Document available free of charge
|
|
Iranian Journal of Pediatrics, Vol. 21, No. 3, 2011, pp. 362-366
en |
Hirschsprung's Disease: a Clinical and Pathologic Study in Iranian Constipated Children
Monajemzadeh, Maryam; Kalantari, Mehdi; Yaghmai, Bahareh; Shekarchi, Roya; Mahjoub, Fatemeh & Mehdizadeh, Mehrzad
Abstract
Objective: Hirschsprung's disease (HD) is a complex disorder resulting from absence of ganglion
cells in the bowel wall leading to functional obstruction and bowel dilatation proximal to the
affected segment. The aim of our study was to evaluate rectal biopsies from constipated children in
different age groups to see in which age it is more likely to encounter HD to avoid unnecessary
rectal biopsy.
Methods: Records of all children with chronic constipation undergoing a rectal biopsy to exclude
HD were obtained from the files of Children's Medical Center in Tehran, Iran. A detailed
retrospective demographic review, including age of beginning of signs and symptoms was made of
all cases.
Findings: Totally, 172 biopsies were taken from 168 children in a five year period, of which 127
cases (75%) had HD. The mean age of constipated patients at biopsy was 39 months and the mean
age of patients with proven HD was 18 months. Males were affected more than females. Congenital
anomalies associated with HD were found in 9.6%. In 85 (91%) cases constipation had begun in
neonatal period.
Conclusion: Our data supports previous studies that if constipation begins after the neonatal
period, the child is unlikely to have HD. In neonates delay in meconium passage is the most
important clinical sign of HD.
Keywords
Hirschsprung's Disease; Functional Gastrointestinal Disorders; Constipation; Biopsy; Intestinal Obstruction
|
|
© Copyright 2011 Iran Journal of Pediatrics. Alternative site location: http://diglib.tums.ac.ir/pub/
|
|