Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 22, No. 1, 2012, pp. 113-116
Bioline Code: pe12019
Full paper language: English
Document type: Short Communication
Document available free of charge
Iranian Journal of Pediatrics, Vol. 22, No. 1, 2012, pp. 113-116
© Copyright 2012 - Iran Journal of Pediatrics
Correlation between Hypoglycemia and Positive Rate of Inborn Error of Metabolism in Neonatal Intensive Care Unit|
Tu, Wen-jun; He, Jian & Li, Ying
Objective: To investigate the correlation between hypoglycemia and positive rate of inborn error of
metabolism (IEM) in neonatal intensive care unit.
Methods: 160 patients from a neonatal intensive care unit were enrolled. Blood glucose was measured by
Roche Modular chemistry. The dry blood on filter papers, collected from 160 patients, was tested by tandem
mass spectrometry to detect 35 inborn errors of metabolism. Clinical follow-up of all the patients was at least
in an interval of 12 months. The mean observation period was 13.5 months per child.
Findings: Based on the ROC curve, the optimal cut-off value of hypoglycemia as an indicator for screening for
IEMs was projected to be 2.8 mmol/L, which yielded a sensitivity of 71.4% and a specificity of 76.5%. The
patients were divided into two groups: hypoglycemia group (48 cases) and the control group (112 cases).
5(10.4%) of the 48 patients in the hypoglycemia group were positive, while only 2(1.8%) of the 112 patients
in the control group were positive. The difference of the positive rate in the screening for IEMs between the
two groups was significant (χ2=4.10, P<0.05); the relative risk (RR) was 5.83 (95% CI: 1.06-32.12).
Conclusion: The risk of patients with hypoglycemia suffering from IEMs was significantly higher than that of
the non-hypoglycemia patients in NICU, based on cut-off value of 2.8mmol/L.
Neonatal Intensive Care Units; Hypoglycemia; Inborn Errors of Metabolism; Tandem Mass Spectrometry
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