Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 22, No. 3, 2012, pp. 399-403
Bioline Code: pe12071
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 22, No. 3, 2012, pp. 399-403
© Copyright 2012 - Iranian Journal of Pediatrics
Oral Clonidine Premedication Reduces Nausea and Vomiting in Children after Appendectomy|
Alizadeh, Reza; Mireskandari, Seyed-Mohammad; Azarshahin, Mitra; Darabi, Mohammad-Esmaeil; Padmehr, Roya; Jafarzadeh, Afshin & Aghsaee-Fard, Ziba
Objective: Clonidine is an α2-agonist which is used as a sedative premedication in children. There are
conflicting results in the published literature about the effect of clonidine on the incidence of post operative
nausea and vomiting (PONV). We therefore decided to evaluate the effect of oral clonidine given
preoperatively on the incidence of PONV in children after appendectomy.
Methods: sixty children, 5-12 years old, classified as American Society of Anesthesiologists physical status I
and II, who were scheduled for appendecectomy were enrolled in this randomized double blinded clinical
trial. Patients were randomly assigned into two groups of 30 patients. Patients in clonidine group were given
4 μg.kg -1 clonidine in 20 cc of apple juice and patients in control group were given only 20 cc of apple juice 1
hour before transporting to operating room. The protocol of general anesthesia and postoperative analgesia
was the same for two groups. Incidence of PONV and antiemetic usage of patients were assessed during 0-24
hours after anesthesia.
Findings: The patients' characteristics were similar in two groups. Patients who had received clonidine had
significantly less episodes of PONV and also less rescue antiemetic usage than patients in control group.
Conclusion: we showed that oral clonidine at a dose of 4 μg.kg -1 administered preoperatively is associated
with a reduced incidence of postoperative vomiting in children who have undergone appendectomy.
Clonidine; Appendectomy; Vomiting; Clinical trial
Alternative site location: http://diglib.tums.ac.ir/pub/