|
Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 22, No. 3, 2012, pp. 408-411
|
Bioline Code: pe12073
Full paper language: English
Document type: Short Communication
Document available free of charge
|
|
Iranian Journal of Pediatrics, Vol. 22, No. 3, 2012, pp. 408-411
en |
Tuberous Sclerosis Complex in Autism
Guo, Xin; Tu, Wen-Jun & Shi, Xiao-Dong
Abstract
Objective: To study the prevalence rate of tuberous sclerosis complex in autistic disorder.
Methods: We studied one cohort of children followed up since 2005 until 2009, with autistic disorder, to
determine the incidence of tuberous sclerosis complex. We established an autistic disorder registry in 2005 at
China Rehabilitation Research Center. During the 4-year period (2005–2009), we collected a database of 429
children (390 boys and 39 girls; male to female ratio 10:1) with autistic disorder and pervasive
developmental disorders. We routinely examined all children with autistic disorder for any features of
tuberous sclerosis complex by looking for neurocutaneous markers such as depigmented spots. In those with
infantile spasm or epilepsy, the clinical features of tuberous sclerosis complex were monitored regularly
during follow-up.
Findings: Of these, five had tuberous sclerosis complex. Thus, the prevalence rate of tuberous sclerosis
complex in autistic disorder is 1.17%. All of these children were mentally retarded with moderate to severe
grades. Their IQ or developmental quotient was less than 70.
Conclusion: The prevalence rate of tuberous sclerosis complex in autistic disorder was 1.17% in our region;
autism spectrum disorder is a condition that might be associated with development of tuberous sclerosis
complex.
Keywords
Tuberous Sclerosis Complex; Autism; Autistic Disorder; Neurocutaneous Syndromes
|
|
© Copyright 2012 - Iranian Journal of Pediatrics Alternative site location: http://diglib.tums.ac.ir/pub/
|
|