Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 22, No. 4, 2012, pp. 519-523
Bioline Code: pe12095
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 22, No. 4, 2012, pp. 519-523
© Copyright 2012 - Iranian Journal of Pediatrics
Assessment of Left Atrial Ejection Force in Mildly Asphyxiated Newborns|
Kiani, Abdolrazagh; Shabanian, Reza; Rekabi, Mahsa; Kocharian, Armen & Heidari-Bateni, Giv
Objective: Asphyxia-induced cardiac insult is one of the major causes of mortality and morbidity in the course
of perinatal asphyxia. Nowadays, a remarkable trend of interest is sensed introducing a plausible modality for
early detection of cardiac insults at the beginning stages of asphyxia. In this study we aimed to evaluate
diagnostic utility of transmitral Doppler–derived parameters as well as left atrial ejection force index as a
marker of left atrial contractile function in these patients.
Methods: In a prospective study selected cases of 26 asphyxiated newborns with preserved systolic function
underwent conventional transmitral Doppler flow echocardiographic assessment. Left atrial ejection force
index was further calculated for all patients. Data was compared with normal ranges of healthy newborns in
order to clarify the diagnostic utility of these parameters for determining minor cardiac insults in this age
Findings: We found that mildly asphyxiated newborns showed an increase in the values of left atrial ejection
force index (5.44±2.12 kilodyne vs. 6.66±2.17 kilodyne, P= 0.02) and left atrial filling fraction (39%±10% vs.
45%±8%, P= 0.01). Furthermore, the acceleration and deceleration rate of early filling flow peak velocity
were decreased in this group of asphyxiated newborns.
Conclusion: Assessment of left atrial ejection force in mildly asphyxiated newborns reveals that newborns
with even mild asphyxia, although could not be categorized in conventional grading system, suffer to some
extent from a ventricular filling abnormality. This type of latent ventricular filling abnormality could simply
be unmasked by calculation of atrial ejection force index.
Neonate; Newborn; Asphyxia; Echocardiography; Atrial Function; Atrial Ejection Force
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