Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 23, No. 1, 2013, pp. 105-108
Bioline Code: pe13018
Full paper language: English
Document type: Case Report
Document available free of charge
Iranian Journal of Pediatrics, Vol. 23, No. 1, 2013, pp. 105-108
© Copyright 2013 - Iran Journal of Pediatrics
Generalized Lymphadenopathy in Infancy; a Case Report|
Mamishi, Setareh; Movahedi, Zahra; Mohammadzadeh, Vahid & Sabouni, Farah
Background: Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical
lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are
also some reports on involvement of other human body organs with or without LAP.
Case Presentation: A 7-month-old infant with chief complaint of generalized massive LAP was referred to our
center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and
immunoreactivity study on the obtained sample by cervical lymph node biopsy.
Conclusion: RDD is not a malignant illness and lymph node enlargement most often decreases in its size
happens without special treatment.
Rosai-Dorfman Disease; Generalized Lymphadenopathy; Infant; Histiocytosis
Alternative site location: http://diglib.tums.ac.ir/pub/