Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 23, No. 2, 2013, pp. 194-198
Bioline Code: pe13035
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 23, No. 2, 2013, pp. 194-198
© Copyright 2013 - Iran Journal of Pediatrics
Is There any Association Between Passive Smoking and Esophagitis in Pediatrics?|
Monajemzadeh, Maryam; Haghi-Ashtiani, Mohammad-Taghi; Soleymani, Roohallah; Shams, Sedigheh; Taleb, Shayandokht; Motamed, Farzaneh; Najafi, Mehri & Abbasi, Ata
Objective: Exposure to environmental tobacco smoke (ETS) is one of the major factors of predisposing
children to develop several hazardous health problems. We decided to investigate the association between
nicotinine, one of the nicotine metabolites and esophagitis in children with gastroesophageal reflux
Methods: In a case control study 46 children suffering from esophagitis referred to endoscopy ward were
recruited. The control group consisted of 45 healthy children. Urine samples were collected and urinary
cotinine level (UCL) measured.
Findings: The mean age of esophagitis and control groups were 5.11±2.93 and 6.72±2.8 respectively. Sixty
children were passive smokers; 31 of them had non-smoker parents. In control group, 32 (71.1%) children
and in esophagitis group 29 (63%) children had non-smoker parents. The mean value of UCL in patients
suffering from esophagitis was significantly higher than those in normal group (P=0.04, 24.98±6.4 ng/ml vs.
15.16 ± 3.9 ng/ml). Considering 50ng/ml as a cutoff point for UCL, it was significantly higher in passive
smoker group than in non smoker group (P=0.02). The mean cotinine level differed significantly in
esophagitis and control group.
Conclusion: Our results indicate the increased risk of developing esophagitis in children with ETS exposure.
Cotinine; Children; Esophagitis; Passive Smoking
Alternative site location: http://diglib.tums.ac.ir/pub/