Short-Term Outcomes of Very Low Birth Weight Infants Born at a Tertiary Care Hospital, Istanbul, Turkey|
Atalay, Deniz; Salihoğlu, Özgül; Can, Emrah; Beşkardeş, Ayşegül & Hatipoğlu, Sami
Objective: To evaluate mortality and short-term outcomes in very low birth weight infants admitted to the
tertiary neonatal intensive care unit, Istanbul, Turkey.
Methods: Study data were recorded prospectively from January 1, 2010, to December 31, 2010. The clinical
findings in neonates with birth weights <1000g were compared with infants with birth weights of between
1000g and 1499g.
Findings: In the present study, survival rates were 40% and 86.2% for infants weighing <1000g and 1000g to
1499g, respectively. There was no difference between males and females with respect to mortality (P>0.05).
The mean (±standard deviation) birth weight was 985.6±150.15 g and mean gestational age was 27.5±2.04
weeks. The antenatal steroid rate was 37.2%, and the Cesarean section rate was 73%. Respiratory distress
syndrome was diagnosed in 89% of the infants, with a 69% surfactant administration rate. Severe intracranial
hemorrhage (IVH) (grade >II) was 14%. Grade 4 periventricular leukomalacia was 10%. Twelve (24%)
infants had evidence of bronchopulmonary dysplasia (BPD). Retinopathy of prematurity (stage >II) was 4%.
The correlation between ROP rate and need for ventilation therapy was present (r=0.52). Proven necrotizing
enterocolitis (stage >2) was not observed. Patent ductus arteriosus (PDA) was diagnosed in 67% of the
neonates. BPD, IVH, and PDA were statistically higher in neonates with a birth weight <1000g.
Conclusion: Survival rate of VLBW infants increased with increasing BW. Sex was not a risk factor for
mortality. The need for ventilatory therapy may be an important risk factor for ROP in infants < 1500g.
Mortality; Morbidity; Neonate; Very Low Birth Weight