Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children|
Guo, Cheng & Chen, Li
Objective: To evaluate the diagnostic value of provocative test by insulin combined with clonidine for growth
hormone deficiency (GHD) during childhood
Methods: Eighty children underwent a provocative test with insulin(0.075U/Kg, intravenous) combined with
clonidine (4μg/kg, orally). Among them, 40 children underwent clonidine provocative test, 40 children
underwent insulin tolerance test (ITT) in another day.
Findings: The specificity of ITT+clonidine test (74%, 88%) was remarkably higher than that of ITT (48%) or
clonidine test (65%). ITT+clonidine test had a better accuracy (75%, 85%) than that of ITT (63%) or
clonidine test (73%)
Conclusion: We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time
saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT.
Clonidine; Insulin; Growth Hormone; Growth Hormone Deficiency; Short Stature