Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 23, No. 3, 2013, pp. 345-348
Bioline Code: pe13064
Full paper language: English
Document type: Short Communication
Document available free of charge
Iranian Journal of Pediatrics, Vol. 23, No. 3, 2013, pp. 345-348
© Copyright 2013 - Iranian Journal of Pediatrics
Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients|
Yuan, Li-ping; Bo, Yan; Ling, Lu & Bo, Hu
Objective: To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3)
and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from Henoch-
Schoenlein Purpura (HSP) patients.
Methods: Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine
the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were
used to examine the levels of serum IFN-γ and immunoglobulin A1 (IgA1). The Spearman rank test was used
for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-γ and IgA1 levels,
Findings: The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients,
which was closely correlated with serum IFN-γ and IgA1, respectively.
Conclusion: The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP.
Henoch-Schoenlein Purpura; T-cell Immunoglobulin; Mucin domain containing 3 protein; TIM-3 protein; Immunoglobulin A
Alternative site location: http://diglib.tums.ac.ir/pub/