A Novel Method for Quantification of Left Ventricular Noncompaction Using Two-Dimensional Echocardiography in Children|
Khosroshahi, Ahmad Ghamei; Zanjani, Keyhan Sayadpour; Kocharian, Armen; Zeinaloo, Aliakbar; Kiani, Abdolrazagh & Rad, Elaheh Malakan
Objective: Although there are several echocardiographic criteria, there is not yet a general consensus about
the diagnosis of left ventricular noncompaction. The current criteria are mostly based on the areas with
maximal noncompaction in the heart. The echocardiographer may miss this maximal point leading to a
misdiagnosis. Accordingly, we suggested a new method to measure the percentage of myocardial
noncompaction using two-dimensional echocardiography.
Methods: In this study, the new method was examined on 4 noncompaction and 26 dilated cardiomyopathies,
and 25 normal subjects. The percentage of noncompaction was measured at 3 levels (apical, papillary muscle
and mitral valve) and averaged.
Findings: The mean percentages of myocardial noncompaction were 3.59±2.27, 8.86±5.52 and 34.7±26.1 in
the control, dilated cardiomyopathy and noncompaction groups, respectively. A value of 17% or greater could
distinguish left ventricular noncompaction from dilated cardiomyopathy with 92% specificity and 100%
sensitivity and from normal subjects with 100% specificity and sensitivity. This percentage had a statistically
significant association with noncompacted to compacted myocardial thickness ratio (P<0.001).
Conclusion: This method showed good correlations with the existing echocardiographic and magnetic
resonance criteria. However, it is not dependent on finding the area of maximal involvement. Being
comparable to magnetic resonance imaging in accuracy, it is easier to perform and more available.
Left Ventricular Noncompaction; Cardiomyopathy; Echocardiography; Children