Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 23, No. 5, 2013, pp. 525-530
Bioline Code: pe13099
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 23, No. 5, 2013, pp. 525-530
© Iranian Journal of Pediatrics
Clinical Significance of the Dynamic Changes in Serum Eotaxin, Interleukin 13 and Total IgE in Children with Bronchial Asthma|
Wang, Xin; Ma, Chunyan; Zhang, Yajing; Ning, Lihua; Chen, Hua & Zhou, Fang
Objective: To determine the serum levels of eotaxin, IL-13 and total IgE (TIgE) in asthmatic children during
the acute and clinical remission periods, as well as the changes in pulmonary function to determine their
roles, relationships and clinical significance during asthma exacerbation.
Methods: A total of 30 asthmatic children and 22 healthy children were enrolled in the study. The serum
eotaxin and IL-13 levels were detected using an enzyme-linked immunosorbent assay and the TIgE level was
detected using a fluorescent enzyme-linked immunosorbent assay. The asthmatic children were subjected to
pulmonary function tests.
Findings: The serum eotaxin, IL-13 and TIgE levels of the asthmatic children during the acute period
significantly differed from those during clinical remission. The serum eotaxin, IL-13 and TIgE levels of the
asthmatic children during both periods significantly differed from those of healthy children (P<0.001). The
serum eotaxin levels during the acute and clinical remission periods were positively correlated with serum IL-
13 and with TIgE, and serum IL-13 was correlated with serum TIgE. The pulmonary function indices of
asthmatic children during the acute period significantly differed from those during clinical remission
(P<0.001). The serum eotaxin and IL-13 levels in the asthmatic children were positively correlated with the
forced expiratory volume in 1 second (FEV1) and the peak expiratory flow (PEF) during the acute and clinical
remission periods (P<0.05). However, the serum TIgE levels in asthmatic children were not significantly
correlated with the FEV1 and PEF during both periods (P>0.05).
Conclusion: Serum TIgE, IL-13 and eotaxin influence each other during exacerbation of bronchial asthma and
influence the corresponding pathophysiologic changes. Serum IL-13 and eotaxin could be used as markers for
evaluating the severity of bronchial asthma.
Asthma; Eotaxin; interleukin 13; Total IgE; Pulmonary Function; Children
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