Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 23, No. 6, 2013, pp. 659-663
Bioline Code: pe13140
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 23, No. 6, 2013, pp. 659-663
© Copyright 2013 - Iranian Journal of Pediatrics
Resistin in Cord Blood of Small for Gestation Age and Appropriate for Gestation Age Term Neonates|
Davari Farid, Sina; Najati, Naiere; Mostafa Gharebaghi, Manizheh; Ghorbani Haghjo, Ali & Ghojazadeh, Morteza
Objective: Placental hormones such as resistin, adiponectin, ghrelin and leptin are known to have
considerable role in fetal growth and there are some articles published in this area recently. Nevertheless
there is a shortage of data showing association between resistin level and fetal growth; that was why we
decided to conduct a study to evaluate this association.
Methods:This study was approved by ethic committee of pediatric health research center and research vice
chancellor of Tabriz University of Medical Sciences. In this case-control study we measured the insulin,
glucose and resistin in the cord blood of neonates with gestational age of 37 weeks or more in Al Zahra
tertiary hospital from March 2011 to March 2012. Thirty-nine appropriate for gestation age (AGA) neonates
and 41 small for gestation age (SGA) neonates were studied.
Findings:The umbilical cord blood resistin level was not found to have significant correlation with the type of
delivery [normal vaginal delivery (NVD) or cesarean-section (C-S)], neonate's gender, maternal age or body
mass index (BMI). There was no significant difference in the levels of Insulin and glucose between AGA and
SGA groups. Resistin level of blood cord in AGA group was 613.76±180.10 (range: 132.6-983.80 ng/ml) and in
SGA group it was 1303.47±537.07 (range: 800.9-3001 ng/ml) (P<0.001). Neonates’ weight in AGA group was
3162.82±407.92 g and in SGA group it was 2425.85±32.84 g (P<0.001).
Conclusion: In this study resistin level had reverse correlation with fetal weight in term neonates. The SGA
neonates with growth insufficiency have higher resistin levels in their cord blood than AGA neonates with
same gestational age. It is recommended to conduct more studies in future with larger population of patients
to clarify the resistin role in neonatal birth weight.
Small for Gestational Age; Appropriate for Gestational Age; Resistin; Insulin; Glucose
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