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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 24, No. 2, 2014, pp. 166-172
Bioline Code: pe14030
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 24, No. 2, 2014, pp. 166-172

 en Evaluation of Oxidative Stress and Erythrocyte Properties in Children with Henoch-Shoenlein Purpura
Gurses, Dolunay; Parlaz, Nusret; Bor-Kucukatay, Melek; Kucukatay, Vural & Erken, Gulten

Abstract

Objective: Pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly defined. The present study was conducted to investigate the alterations in erythrocyte deformability and oxidative stress in HSP and to examine the possible relationship between erythrocyte deformability and organ involvement in this disease.
Methods: Plasma malondialdehyde (MDA) levels, total antioxidant status (TAS), erythrocyte deformability and aggregation were measured in 21 children with HSP at the disease onset and during the remission period in comparison with healthy subjects.
Findings: HSP patients at the active stage had significantly higher MDA and lower TAS levels (P<0.05). Erythrocyte deformability was decreased at the active-stage and increased again at the remission period of HSP (P<0.05). Erythrocyte deformability was significantly decreased at four different shear stresses in patients with gastrointestinal system or renal involvement; and decreased at six different shear stresses in patients with gastrointestinal system, and renal involvement compared to the patients without organ involvement (P<0.05). No significant difference was observed in aggregation parameters (P>0.05).
Conclusion: The present findings emphasize the association between impaired erythrocyte deformability and organ involvement in HSP.

Keywords
Erythrocyte Aggregation; Erythrocyte Deformability; Henoch-Schönlein Purpura; Malondialdehyde; Oxidative Stress

 
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