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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 25, No. 5, 2015, pp. 1-4
Bioline Code: pe15071
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 25, No. 5, 2015, pp. 1-4

 en Cord Blood Alkaline Phosphatase as an Indicator of Neonatal Jaundice
Ahmadpour-Kacho, Mousa; Pasha, Yadollah Zahed; Haghshenas, Mohsen; Rad, Zahra Akbarian; Firouzjahi, Alireza; Bijani, Ali; Dehvari, Abdollah & Baleghi, Mehrangiz


Background: Management of hyperbilirubinemia remains a challenge for neonatal medicine because of the risk of neurological complications related to the toxicity of severe hyperbilirubinemia.
Objectives: The purpose of this study was to examine the validity of cord blood alkaline phosphatase level for predicting neonatal hyperbilirubinemia.
Patients and Methods: Between October and December 2013 a total of 102 healthy term infants born to healthy mothers were studied. Cord blood samples were collected for measurement of alkaline Phosphatase levels immediately after birth. Neonates were followed-up for the emergence of jaundice. Newborns with clinical jaundice were recalled and serum bilirubin levels measured. Appropriate treatment based on serum bilirubin level was performed. Alkaline phosphatase levels between the non-jaundiced and jaundiced treated neonates were compared.
Results: The incidence of severe jaundice that required treatment among followed-up neonates was 9.8%. The mean alkaline phosphatase level was 309.09 ± 82.51 IU/L in the non-jaundiced group and 367.80 ± 73.82 IU/L in the severely jaundiced group (P = 0.040). The cutoff value of 314 IU/L was associated with sensitivity 80% and specificity 63% for predicting neonatal hyperbilirubinemia requiring treatment.
Conclusions: The cord blood alkaline phosphatase level can be used as a predictor of severe neonatal jaundice.

Fetal Blood; Hyperbilirubinemia; Jaundice; Alkaline Phosphatese; Newborn

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