Background: Helicobacter Pylori
infects around 50% of the human population and is asymptomatic in 70% of the cases. H.pylori
eradication in childhood will not only result in peptic symptoms relief, but will also prevent late-term complications such as cancer. Today, probiotics are being increasingly studied in the treatment of gastrointestinal infections as an alternative or complement to antibiotics.
In this study we aimed to assess the effect of S. boulardii
supplementation on H.pylori
eradication among children in our region.
Patients and Methods:
In this randomized double-blind placebo-controlled clinical trial 28 asymptomatic primary school children with a positive H.pylori
stool antigen (HpSA) exam were randomly allocated into the study group, receiving Saccharomyces Boulardii
and the control group receiving placebo capsules matched by shape and size, for one month. The children were followed up weekly and were reinvestigated four to eight weeks after accomplished treatment by HpSA testing. The significance level was set at P < 0.05.
24 children completed the study. The mean HpSA reduced from 0.40 ± 0.32 to 0.21 ± 0.27 in the study group, indicating a significant difference (P = 0.005). However, such difference was not observed in the control group (P = 0.89). Moreover, the HpSA titer showed a 0.019 ± 0.19 decrease in the study group whereas the same value was 0.0048 ± 0.12 for the controls, again stating a significant difference (P = 0.01).
Conclusions: Saccharomyces boulardii
has a positive effect on reducing the colonization of H.pylori
in the human gastrointestinal system but is not capable of its eradication when used as single therapy.