Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 26, No. 2, 2016, pp. 1-4
Bioline Code: pe16016
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 26, No. 2, 2016, pp. 1-4
© Copyright 2016 - Iranian Journal of Pediatrics
Cytomegalovirus and Langerhans Cell Histiocytosis: Is There a Link?|
Khoddami, Maliheh; Nadji, Seyed-Alireza; Dehghanian, Paria; Vahdatinia, Mahsa & Shamshiri, Ahmad-Reza
Langerhans cell histiocytosis is a rare proliferative histiocytic disease of unknown etiology. Histologically, it is characterized by granuloma-like proliferation of Langerhans-type dendritic cells derived from bone marrow. Many investigators have suggested the possible role of viruses such as Epstein-Barr virus, human herpesvirus-6 (HHV-6), herpes simplex virus (HSV) types 1 and 2, and Cytomegalovirus in the pathogenesis of Langerhans cell histiocytosis.
In this study, we have investigated the presence of Cytomegalovirus in Langerhans cell histiocytosis in Iranian children.
Patients and Methods:
In this retrospective study, we have investigated the presence of Cytomegalovirus DNA expression, using paraffin-embedded tissue samples of 30 patients with Langerhans cell histiocytosis and 30 age and site-matched controls by qualitative Polymerase Chain Reaction (PCR) method.
No significant difference in prevalence of Cytomegalovirus presence between patients and controls was found. Cytomegalovirus was found by qualitative PCR in only 2 (6.66%) out of 30 patients and in 1 (3.3%) of 30 control samples with a P value of 1 (1.00 > 0.05) using chi-square test with OR: 2.07; 95% CI of OR: 0.18 - 24.15.
Our findings do not support the hypothesis of a possible role for Cytomegalovirus in the pathogenesis of Langerhans cell histiocytosis.
Langerhans Cell Histiocytosis, Cytomegalovirus, Polymerase Chain Reaction
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