The levels of Th1
cytokine can alter in pathogenic infection in children with pneumonia.
To evaluate Th1
cytokine profile and its diagnostic value in M. pneumoniae
pneumonia in children.
Patients and Methods:
Children with M. pneumoniae
mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae
in children with pneumonia.
Results: M. pneumoniae
test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae
incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae
mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae
pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001).
IL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae
pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice.