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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 26, No. 2, 2016, pp. 1-4
Bioline Code: pe16019
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 26, No. 2, 2016, pp. 1-4

 en Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae check for this species in other resources Pneumonia
Li, Wei; Liu, Yu-jie; Zhao, Xiao-le; Shang, Shi-qiang; Wu, Lang; Ye, Qing & Xu, Hui

Abstract

Background:
The levels of Th1/Th2 cytokine can alter in pathogenic infection in children with pneumonia.
Objectives:
To evaluate Th1/Th2 cytokine profile and its diagnostic value in M. pneumoniae check for this species in other resources pneumonia in children.
Patients and Methods:
Children with M. pneumoniae mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae in children with pneumonia.
Results:
M. pneumoniae test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001).
Conclusions:
IL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice.

Keywords
Cytokines, Pneumonia, Children, M. pneumoniae

 
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