Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 26, No. 3, 2016, pp. 19-22
Bioline Code: pe16031
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 26, No. 3, 2016, pp. 19-22
© Copyright - 2016 Iranian Journal of Pediatrics
Evaluation of Serum Adenosine Deaminase in Cystic Fibrosis Patients in an Iranian Referral Hospital|
Farahmand, Fatemeh; Tajdini, Parisa; Falahi, Gholamhossein; Shams, Sedigheh & Mahmoudi, Shima
Background: Adenosine, a signaling nucleoside, is controlled in part by the enzyme adenosine deaminase (ADA). There are rare
reports on the role of adenosine levels and ADA in cystic fibrosis (CF) patients.
Objectives: The aim of this study was to assess serum ADA in CF patients in order to find whether the severity of lung disease in CF
is related to significant changes of ADA or not.
Patients and Methods: Venous blood serum ADA was measured in CF patients (3-15 years) and 49 healthy children (3-15 years) referred
to Children’s Medical Center. Classification of respiratory and gastrointestinal disease severity in CF patients as well as Body
Mass Index (BMI) was performed. The results were compared with values obtained from healthy children matched for age and gender.
Results: This study included 49 children of both genders (20 females and 29 males) with CF (mean age: 6.36 ± 2.22 years). Mean
serum ADA in CF patients group and control group was 9.38 ± 2.72 and 16.04 ± 1.27, respectively (P value = 0.001). Mean serum ADA
in CF patients with normal BMI was higher than in patients with low BMI (P value = 0.002).
Conclusions: In this study the lower serum level of ADA was seen in CF patients compared to control group. The clinical symptoms,
especially respiratory symptoms, in CF patients might be associated with reduction of serum ADA and rising serum adenosine;
therefore, further studies on the use of ADA enzyme therapy in CF patients are highly recommended.
Adenosine Deaminase; Cystic Fibrosis; Children
Alternative site location: http://diglib.tums.ac.ir/pub/