Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 26, No. 3, 2016, pp. 68-71
Bioline Code: pe16038
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 26, No. 3, 2016, pp. 68-71
© Copyright - 2016 Iranian Journal of Pediatrics
Evaluation of Serum Zinc Levels in Hyperbilirubinemic Neonates Before and After Phototherapy|
Mosayebi, Ziba; Rahmani, Maral; Ardakani, Shahin Behjati; Sheikh, Mahdi; Shariat, Mamak & Rezaeizadeh, Golnaz
Background: The existing therapeutic methods for neonatal jaundice are costly, time-consuming and potentially risky. Zinc salts
can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine (bilirubin and zinc can form a complex
in physiologic pH); however, zinc toxicity isanissue thatmustbe considered since theoretically bilirubin reduction by phototherapy
may increase serum zinc levels, making additional zinc supplementation the potential cause of zinc toxicity.
Objectives: So, our purpose was evaluating the serum zinc level alterations before and after phototherapy, in hyperbilirubinemic
Materials and Methods: A prospective cohort study was performed at the children’s medical center of Tehran University of Medical
Sciences from 2012 to 2014. Healthy, full-term exclusively breast fed newborns with non-hemolytic jaundice were enrolled in the
study. Participants were divided into two groups based on serum bilirubin levels (TSB < 18 mg/dL and TSB 18 mg/dL) at admission.
Pre- and post-phototherapy total serum zinc level was measured before and 12 - 24 hours after termination of phototherapy.
Results: Phototherapy was associated with a significant increase in the serum zinc level in neonates with severe hyperbilirubinemia
(TSB 18 mg/dL) but not in those with mild-moderate hyperbilirubinemia (TSB < 18 mg/dL). In addition, phototherapy caused a
significant increase in the rate of zinc with potentially toxic levels (zinc > 200) in only neonates with severe hyperbilirubinemia.
Conclusions: Phototherapy increases serum zinc level by reducing bilirubin level so that additional supplementation of this element
can lead potentially to zinc toxicity.
Hyperbilirubinemia; Neonate; Zinc; Phototherapy
Alternative site location: http://diglib.tums.ac.ir/pub/