Determination of Age-Dependent Reference Ranges for Coagulation Tests Performed Using Destiny Plus|
Arslan, Fatma Demet; Serdar, Muhittin; Ari, Elif Merve; Oztan, Mustafa Onur; Kozcu, Sureyya Hikmet; Tarhan, Huseyin; Cakmak, Ozgur; Zeytinli, Merve & Ellidag, Hamit Yasar
Background: In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted
with age-appropriate reference ranges.
Objectives: The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated
partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests.
Materials and Methods: A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5
years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic
system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence
intervals, were calculated.
Results: No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus,
the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children
than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other
groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established.
Conclusions: These results support other findings related to developmental hemostasis, confirming that adult and pediatric age
groups should be evaluated using different reference ranges.
Reference Ranges; Age Groups; Blood Coagulation Tests