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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 26, No. 3, 2016, pp. 89-96
Bioline Code: pe16041
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 26, No. 3, 2016, pp. 89-96

 en Determination of Age-Dependent Reference Ranges for Coagulation Tests Performed Using Destiny Plus
Arslan, Fatma Demet; Serdar, Muhittin; Ari, Elif Merve; Oztan, Mustafa Onur; Kozcu, Sureyya Hikmet; Tarhan, Huseyin; Cakmak, Ozgur; Zeytinli, Merve & Ellidag, Hamit Yasar

Abstract

Background: In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges.
Objectives: The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests.
Materials and Methods: A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5 years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence intervals, were calculated.
Results: No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established.
Conclusions: These results support other findings related to developmental hemostasis, confirming that adult and pediatric age groups should be evaluated using different reference ranges.

Keywords
Reference Ranges; Age Groups; Blood Coagulation Tests

 
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