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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 2008-2150
Vol. 26, No. 4, 2016, pp. 1-8
Bioline Code: pe16047
Full paper language: English
Document type: Review Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 26, No. 4, 2016, pp. 1-8

 en Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis
Sedighi, Iraj; Karimi, Abdollah & Amanati, Ali

Abstract

Context: Universal immunization against Bordetella pertussis check for this species in other resources has partially controlled the burden of the disease and its transmission. However, according to recent data, the epidemiology of this vaccine-preventable disease has changed. Now, younger infants, adolescents, and adults are at greater risk of infection. This article has studied the interaction between the various factors involved in the changing epidemiology of pertussis and the major obstacles faced by the current strategies in its prevention.
Evidence Acquisition: In this narrative review, the most recently published sources of information on pertussis control measures, consisting of textbooks and articles, have been reviewed. We focused on the more recent data about the changing epidemiology or pertussis in Scopus through the use of the MeSH-term words [pertussis] or [whooping cough] and [epidemiology] or [outbreak] or [resurgence], but our search was not restricted to this particular strategy; we also tried to find all of the most recent available data in the general field through other means.
Results: Primary and booster doses of the pertussis vaccine seem to partially control transmission of the disease, but despite the different preventive strategies available, pertussis continues to cause mortality and morbidity among high-risk groups.
Conclusions: Adding booster doses of acellular pertussis vaccine to the current national immunization practices with whole-cell vaccines for young adults and pregnantwomenseems to be a good option for controlling mortality and morbidity among high-risk groups such as very young infants.

Keywords
Bordetella pertussis; Prevention and Control; Immunization; Pertussis Vaccine

 
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