Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 26, No. 4, 2016, pp. 87-92
Bioline Code: pe16061
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 26, No. 4, 2016, pp. 87-92
© Copyright 2016 - Iranian Journal of Pediatrics
Potential of Serum and Urinary Matrix Metalloproteinase-9 Levels for the Early Detection of Renal Involvement in Children With Henoch-Schönlein Purpura|
Erol, Meltem; Yigit, Ozgul; Tasdemir, Mehmet; Gayret, Ozlem Bostan; Buke, Ovgu; Gunes, Aysegul; Hamilcikan, Sahin & Kasapcopur, Ozgur
Background: Matrix metalloproteinase-9 (MMP-9) is an enzyme implicated in the pathogenesis of renal diseases. Renal involvement
is the principal cause of morbidity and mortality in children with Henoch-Schönlein purpura (HSP).
Objectives: The aim of this study was to evaluate whether serum and urinary MMP-9 levels are associated with renal involvement
Patients and Methods: We evaluated 40 children with HSP (patient group) and 27 healthy volunteer children (control group).
The patient group was divided into two subgroups based on the presence or absence of nephritis. Nephritis was defined as the
existence of hematuria and/or proteinuria. All anthropometric data, physical examination findings, blood pressure, and laboratory
parameters were recorded. The serum and urine samples were analyzed to determine the MMP-9 levels three days after the initial
phase of the disease.
Results: The mean age was 7.65 ±; 3.41 (range 2 - 16) years in the patient group and 9.52 ± 3.91 (range 2 - 16) years in the control group.
Henoch-Schonlein purpura nephritis (HSPN) was identified in eight patients. There was no significant difference in the serum MMP-
9 levels between the HSPN subgroup and the controls (P > 0.05). However, there were significant differences in the urinary MMP-9
levels between the HSP subgroup and the control group (P < 0.05), with the urinary MMP-9 levels being significantly higher in
patients in the HSP subgroup (P = 0.001). Further, the urinary MMP-9 levels were significantly higher in the patients with nephritis
than in the patients without nephritis (P = 0.001) and the controls (P = 0.001). The optimal cut-off point (sensitivity; specificity) of
the urinary MMP-9 level for the diagnosis of HSPN was 94.7 pg/mL.
Conclusions: The levels of MMP-9 in the urine were remarkably high in patients with HSPN. This non-invasive markermaytherefore
be an important indicator for the early diagnosis of nephritis in children with HSP.
Henoch-Schönlein Purpura; Henoch-Schönlein Purpura Nephritis; Matrix Metalloproteinase-9
Alternative site location: http://diglib.tums.ac.ir/pub/