The Effects of Nutrition, Exercise, and a Praying Program on Reducing Iron Overload in Patients With Beta-Thalassemia Major: A Randomized Clinical Trial|
Molazem, Zahra; Noormohammadi, Roghaye; Dokouhaki, Roya; Zakerinia, Maryam & Bagheri, Zahra
Background: Excessive iron accumulation in the visceral organs creates problems for patients with beta-thalassemia major. Despite
chelation therapy, mortality rate from the complications of this disease is still quite high.
Objectives: This study aimed to investigate the effectiveness of nutrition, exercise, and a praying program at reducing iron overload
in patients with beta-thalassemia major.
Patients and Methods: This randomized clinical trial assessed the effect of the designed care program on iron overload. The study
was conducted in 38 patients with beta-thalassemia major who ranged in age from 15 - 35 years and had been referred to the largest
center for thalassemic patients in Shiraz. The patients were randomly assigned to an intervention (n = 18) and a control (n = 20)
group. Blood samples were collected from the participants before and two months after the intervention. Then, the data were
statistically analyzed using chi-square, Fisher’s exact test, Mann-Whitney U-test, Wilcoxon, independent samples t-test, and paired
Results: The results showed that the mean level of serum ferritin significantly decreased in the intervention group two months
after beginning the intervention. Also, the mean level of serum iron decreased in the intervention group, but the difference was not
Conclusions: The planned educational program could be used to reduce iron overload and ultimately improve the patients’ health
Beta-Thalassemia Major; Exercise; Iron; Ferritin; Nutrition; Praying