Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
Vol. 26, No. 5, 2016, pp. 92-97
Bioline Code: pe16078
Full paper language: English
Document type: Research Article
Document available free of charge
Iranian Journal of Pediatrics, Vol. 26, No. 5, 2016, pp. 92-97
© Copyright - 2016 Iranian Journal of Pediatrics
The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Gastrointestinal Bleeding in Henoch-Schonlein Purpura|
Gayret, Ozlem Bostan; Erol, Meltem & Nacaroglu, Hikmet Tekin
Objectives: Henoch-Schonlein Purpura (HSP) is the most widespread systemic vasculitis during childhood. Gastrointestinal tract
retention and gastrointestinal bleeding are among its major complications. Neutrophil-Lymphocyte ratio (NLR) and plateletlymphocyte
ratio (PLR) are indicators related to inflammatory diseases. This study evaluated the relationship between NLR or PLR
and gastrointestinal bleeding in HSP.
Methods: The study consisted of 119 patients and 40 healthy children in the same age group. White Blood Cell (WBC) count,
hemoglobin level, platelet count, mean platelet volume (MPV), neutrophil count and lymphocyte count were recorded. The NLR
and PLR were calculated based on the results of complete blood count tests performed during the first visit to the hospital.
Results: The average neutrophil count and NLR of the patients with HSP were found to be significantly increased compared to the
control group (P = 0.0001). No significant difference was observed between the PLR average of HSP and control groups (P = 0.053).
Platelet count average (P = 0.0001) and PLR (P = 0.001) of the patients with gastrointestinal system (GIS) bleeding were found to be
statistically significantly increased compared to those who did not have gastrointestinal bleeding. No significant difference was
found in the NLR of the patients with and without gastrointestinal bleeding (P = 0.060).
Conclusions: While the NLR was significantly increased in patients with HSP in this study, the PLR was found to be more significant
in patients with gastrointestinal bleeding. Similar to NLR, PLR may also be used as an inflammatory indicator among children with
HSP, who have gastrointestinal bleeding.
Henoch-Schonlein Purpura; Neutrophil-Lymphocyte Ratio; Platelet-Lymphocyte Ratio; Gastrointestinal Bleeding
Alternative site location: http://diglib.tums.ac.ir/pub/