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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406 EISSN: 1018-4406
Vol. 27, No. 3, 2017, pp. 1-5
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Bioline Code: pe17054
Full paper language: English
Document type: Research Article
Document available free of charge
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Iranian Journal of Pediatrics, Vol. 27, No. 3, 2017, pp. 1-5
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Relationship Between Fecal Calprotectin and Upper Endoscopy Findings in Children With Upper Gastrointestinal Symptoms
Ataee, Pedram; Afrasiabi, Vahidreza; Nikkhoo, Bahram; Sani, Mehri Najafi; Rahehagh, Ramesh; Ghaderi, Ebrahim; Monajemzadeh, Maryam; Fathollahpour, Asadollah; Sedaghat, Banafsheh & Kariminejhad, Froozan
Abstract
Background: Chronic abdominal pain in children is acommondisorder. For an accurate diagnosis of its cause, sometimes invasive
diagnostic procedures such as endoscopy should be performed.
Objectives: The purpose of the study was to evaluate the fecal calprotectin in children with upper gastrointestinal signs and symptoms
and to compare it with endoscopic findings.
Methods: Atotal of 131 children aged 1-14 years with upper gastrointestinalsymptomswere enrolled during 2012 - 2013 attwo centers.
One hundred and twenty patients underwent endoscopy and biopsy. Before endoscopy, the level of calprotectin was measured by
the enzyme-linked immunosorbent assay test in stool samples and the results were compared with the endoscopic and pathology
findings.
Results: Of the 120 children included in this study, 71 (59.2%) were males and 49 (40.8%) females with a mean age of 93.6 months. Of
the 112 patients in whom biopsies were taken, 16 had esophagitis, 89 chronic gastritis (79.5%) and 57 colonization with Helicobacter pylori.
Conclusions: There was a statistically significant correlation between fecal calprotectin and gastritis and severity of H. pylori infection.
Fecal calprotectin level measurement can avoid unnecessary endoscopies and is also useful for evaluation of therapy response.
Keywords
Endoscopy; Feces; Calprotectin; Gastrointestinal Disease; Children
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© Copyright 2017 - Iranian Journal of Pediatrics Alternative site location: http://diglib.tums.ac.ir/pub/
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