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Iranian Journal of Pediatrics
Tehran University of Medical Sciences Press
ISSN: 1018-4406
EISSN: 1018-4406
Vol. 27, No. 4, 2017, pp. 1-5
Bioline Code: pe17068
Full paper language: English
Document type: Research Article
Document available free of charge

Iranian Journal of Pediatrics, Vol. 27, No. 4, 2017, pp. 1-5

 en ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats
Zhang, Ying; Yuan, Shao-Yong; Zou, Li-Ping; Ding, Ying-Xue & He, Bing

Abstract

Background: Infantile spasm (IS) is a catastrophic epileptic syndrome of childhood and is usually insensitive to conventional antiepileptic drugs. Studies revealed that prenatal stress (PS) exposure and Melanocortin-2 Receptor (MC2R) may be involved in the pathogenesis of IS. However, the exact mechanism still remains unknown.
Methods: In this study, PS was initially given to Wistar rats and ACTH injection was performed in offsprings. Seizure was then induced and evaluated, followed by MC2R immunohistochemistry and expression detection.
Results: Significant differences in seizure number, MC2R and CRH expressions were observed among different subgroups.
Conclusions: Our study suggested that PS exposure may be an important factor in the pathogenesis of IS. ACTH together with low expression of MC2R, may inhibit IS seizures.

Keywords
ACTH; Infantile Spasm; MC2R; Prenatal Stress Exposure

 
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