OBJECTIVE:
To eavaluate the CNS activity of Bramhi Ghrita, a polyherbal formulation containing
Bacopa monneri
,
Evolvulus alsinoids
,
Acorus calamus
,
Saussurea lappa
and
cow′s ghee.
MATERIALS AND METHODS:
The effect of Bramhi Ghrita on motor coordination, behavior, sleep, convulsions, locomotion and analgesia was evaluated in mice using standard procedures.
RESULTS:
The formulation exhibited reduced alertness, spontaneous locomotor activity and reactivity. It also antagonized the behavioral effects of d-amphetamine, potentiated the pentobarbitone-induced sleep and increased the pain threshold. Bramhi Ghrita protected mice from maximum electroshock and pentylene tetrazole-induced convulsions.
CONCLUSION:
The Bramhi Ghrita was found to be a CNS depressant with anticonvulsant. activity
