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Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
EISSN: 0253-7613
Vol. 37, No. 4, 2005, pp. 243-246
Bioline Code: ph05061
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Pharmacology, Vol. 37, No. 4, 2005, pp. 243-246

 en Pharmacological screening and evaluation of antiplasmodial activity of Croton zambesicus   check for this species in other resources against Plasmodium berghei berghei   check for this species in other resources infection in mice
Okokon J.E., Ofodum K.C., Ajibesin K.K., Danladi B., Gamaniel K.S.

Abstract

Objective: To evaluate the antiplasmodial activity of leaf extract of Croton zambesicus   check for this species in other resources on chloroquine-sensitive Plasmodium berghei berghei   check for this species in other resources infection in mice and to confirm its traditional use as a malarial remedy in Africa.
Materials and Methods : The ethanolic leaf extract of Croton zambesicus (50-200 mg/kg) was screened for blood schizontocidal activity against chloroquine-sensitive Plasmodium berghei berghei infection in mice. The schizontocidal activity during early and established infections as well as the repository activity were investigated.
Results: The extract demonstrated a dose-dependent chemosuppression or schizontocidal effect during early and in established infections, and also had repository activity. The activity was lower than that of the standard drugs (chloroquine 5 mg/kg, pyrimethamine 1.2 mg/kg/day).
Conclusion: The leaf extract possesses considerable antiplasmodial activity, which can be exploited in malaria therapy.

Keywords
Malaria, schizontocide

 
© Copyright 2005 Indian Journal of Pharmacology.
Alternative site location: http://www.ijp-online.com

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