The influence of some azoles on wound healing in albino rats

Objective: To investigate the effect of azoles viz metronidazole (MTZ), tinidazole (TNZ), ketoconazole (KCZ), and fluconazole (FLZ) on resutured incision, excision, and dead space wounds in albino rats.
Materials and methods: Resutured incision, excision, and dead space wounds were inflicted in albino rats of either sex under light ether anesthesia, taking aseptic precautions. Control animals received vehicle, and other groups received MTZ, TNZ, KCZ, and FLZ orally for a period of 10 days in incision and dead space wounds, whereas in excision wounds till their complete closure. On the 11th day, after estimating breaking strength of resutured incision wounds (under anesthesia), animals were sacrificed and granulation tissue removed from dead space wounds to estimate breaking strength, hydroxyproline content, quantification of granulation tissue, and histological studies in control and treated groups. In the excision wound model, wound closure rate, epithelization time, and scar features were studied from the day of wounding till the day of scab falling off with no residual raw area.
Results: Except ketoconazole, rest of the azoles significantly (P<0.01, <0.05) promoted the healing process in all the three wound models studied.
Conclusion: Metronidazole, tinidazole and fluconazole promote wound healing, whereas ketoconazole does not do so.